File:Aripiprazole_molecule_from_xtal_ball.png · Wikimedia Commons · See Wikimedia Commons
antipsychotics
Sign in to saveAlso known as antipsychotic agent, antipsychotic drug, major tranquilizer, neuroleptic, antipsychotic agents, antipsychotic, neuroleptics
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In the Vinony graph
Within Vinony's link graph, antipsychotics is referenced by 2,036 other articles, and connects out to zuclopenthixol, tryptamines and valproic acid.
Vinony files it under Antipsychotics, Dopamine antagonists and Psychiatry controversies.
Its subject is documented across 54 Wikipedia language editions.
Key facts
- Drug class.Image
- Aripiprazole molecule from xtal ball.png
- Drug class.Synonyms
- Neuroleptics, major tranquilizers
- Drug class.Caption
- Aripiprazole, the prototypical third-generation atypical antipsychotic
- Drug class.Use
- Principally: Schizophrenia, schizoaffective disorder, dementia, Tourette syndrome, bipolar disorder, irritability in autism spectrum disorder, borderline personality disorder
- Drug class.MeshID
- D014150
via Wikipedia infobox
Research
156,442 papers- [Antipsychotics].Brain and nerve = Shinkei kenkyu no shinpo · 2023Yamada H, Hashimoto RDOI: 10.11477/mf.1416202382
- Antipsychotics and the microbiota.ReviewCurrent opinion in psychiatry · 2020Chen A, Park TY, Li KJ et al.DOI: 10.1097/YCO.0000000000000594
- Antipsychotics and breastfeeding.ReviewJournal of human lactation : official journal of International Lactation Consultant Association · 2001Winans EADOI: 10.1177/089033440101700408
- Antipsychotics in pregnancy.ReviewJournal of psychiatric and mental health nursing · 2010McCauley-Elsom K, Gurvich C, Elsom SJ et al.DOI: 10.1111/j.1365-2850.2009.01481.x
- Antipsychotics-Therapeutic Salve or Iatrogenic Thorn?ReviewPsychopharmacology bulletin · 2026Naguy A, Pridmore S, Abuzeid MY et al.DOI: 10.64719/pb.16602
- Focus on neurodevelopmental conditions and antipsychotics prescription patterns.International clinical psychopharmacology · 2024Serretti ADOI: 10.1097/YIC.0000000000000555
- Viewpoint: do antipsychotics protect against early death? A critical view.ReviewPsychological medicine · 2020Whitaker RDOI: 10.1017/S003329172000358X
- Antipsychotics.ReviewRN · 1997Johnson ST
via PubMed
Wikidata facts
Show 4 more facts
- alternative name
- major tranquilizer
- name
- ataraxic
- Commons category
- Antipsychotic drugs
- NCI Thesaurus ID
- C29710
Sources (6)
via Wikidata · CC0
~84 min read
Encyclopedic overview
55 sectionsContents
- Medical uses
- Schizophrenia
- Prevention of psychosis and symptom improvement
- First-episode psychosis
- Recurrent psychotic episodes
- Maintenance therapy
- Bipolar disorder
- Dementia
- Major depressive disorder
- Other
- Typicals vs atypicals
- Other uses
- Adverse effects
- By rate
- Clozapine
- Long-term effects
- Discontinuation
- Antipsychotic switching
- List of agents
- First-generation (typical)
- Butyrophenones
- Diphenylbutylpiperidines
- Phenothiazines
- Thioxanthenes
- Disputed/unknown
- Benzamides
- Tricyclics
- Others
- Second-generation (atypical)
- Benzamides
- Benzisoxazoles/benzisothiazoles
- Butyrophenones
- Tricyclics
- Others
- Third-generation
- Butyrophenone(s)
- Phenylpiperazines/quinolinones/benzoxazinones
- Muscarinic agonists
- Mechanism of action
- Comparison of medications
- History
- Society and culture
- Terminology
- Sales
- Overprescription
- Legal
- Formulations
- Recreational use
- Controversy
- Special populations
- See also
- Notes
- References
- Further reading
- External links
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. Together with mood stabilizers, they are also a mainstay in the treatment of bipolar disorder. Moreover, they are also used as adjuncts in the treatment of treatment-resistant major depressive disorder.
The use of antipsychotics may result in many unwanted side-effects such as involuntary movement disorders, gynecomastia, impotence, weight-gain and metabolic syndrome. Long-term use can produce adverse effects such as tardive dyskinesia, tardive dystonia, tardive akathisia, and brain-tissue volume-reduction. Withdrawal from antipsychotics can cause insomnia, tremors, and psychotic symptoms.
Excerpted from Wikipedia’s “antipsychotics” article, available under the CC BY-SA 4.0 licence.