File:Midazolam.svg · Wikimedia Commons · See Wikimedia Commons
midazolam
Sign in to saveAlso known as Dormicum®, Versed®, Midazolamum, Dormicum, Buccolam
Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia, premedication before surgical anesthesia, and procedural sedation, and to treat severe agitation. It induces sleepiness, decreases anxiety, and causes anterograde amnesia.
OverviewAI-generated
Midazolam is a chemical compound with the formula C₁₈H₁₃ClFN₃. Its IUPAC name is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. The substance has a mass of 325.078 and a weight of 325.8. It possesses a defined daily dose of 15.
Chemical properties include an xlogp value of 2.5 and a topological polar surface area of 30.2. The molecule contains no hydrogen bond donors and three hydrogen bond acceptors, with a charge of 0. A PubMed query for midazolam yields a count of 18221 entries.
Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459437650
- Drug.image
- Midazolam.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 165
- Drug.image2
- Midazolam-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Versed, others
- Drug.MedlinePlus
- a609003
- Drug.DailyMedID
- Midazolam
- Drug.pregnancy_AU
- C
- Drug.addiction_liability
- Moderate
- Drug.routes_of_administration
- By mouth, intramuscular, intravenous, buccal, intranasal
- Drug.class
- Benzodiazepine
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- CD08
- Drug.legal_AU
- S4
- Drug.legal_BR
- B1
via Wikipedia infobox
Chemical data
- Formula
- C18H13ClFN3
- Molecular weight
- 325.8 g/mol
- IUPAC name
- 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
- SMILES
- CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F
- InChIKey
- DDLIGBOFAVUZHB-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 30.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
18,221 papers- Effects of Midazolam and Dexmedetomidine on Cognitive Dysfunction Following Open-Heart Surgery: A Comprehensive Review.Brain and behavior · 2025
- Midazolam--is antagonism justified?Lancet (London, England) · 1988
- Midazolam for sedation before procedures in adults and children: a systematic review update.Systematic reviews · 2021
- Midazolam: a review of therapeutic uses and toxicity.The Journal of emergency medicine · 1997
- Midazolam.The Australian nurses' journal. Royal Australian Nursing Federation · 1990
via PubMed
Wikidata facts
- Subclass of
- benzodiazepine drug
- Mass
- 325.078
- Manufacturer
- Pfizer
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₈H₁₃ClFN₃
- subject has role
- benzodiazepine drug
- Commons category
- Midazolam
- medical condition treated
- status epilepticus
- canonical SMILES
- CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F
- defined daily dose
- 15
- significant drug interaction
- ritonavir
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
~24 min read
Encyclopedic overview
25 sectionsContents
- Medical uses
- Seizures
- Procedural sedation
- Agitation
- End-of-life care
- Contraindications
- Side effects
- Pregnancy and breastfeeding
- Elderly
- Tolerance, dependence, and withdrawal
- Overdose
- Detection in body fluids
- Interactions
- Pharmacology
- History
- Society and culture
- Cost
- Availability
- Legal status
- Marketing authorization
- Use in executions
- Notable incidents
- Legal challenges
- References
- External links
Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia, premedication before surgical anesthesia, and procedural sedation, and to treat severe agitation. It induces sleepiness, decreases anxiety, and causes anterograde amnesia.
The drug does not cause an individual to become unconscious, merely to be sedated. It is also useful for the treatment of prolonged (lasting over five minutes) seizures. Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek. When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working; when taken orally, it can take 10–20 minutes to begin working.
Excerpted from Wikipedia’s “midazolam” article, available under the CC BY-SA 4.0 licence.