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irazepine

Structure via PubChem · Public domain (PubChem)

EntityQ25100398· pop 6· linked from 539 articles

Also known as Ro 7-1986/1

Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group. It is a non-competitive benzodiazepine binding site antagonist. Irazepine and other alkylating benzodiazepines, such as kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.

Chemical data

Formula
C18H13ClFN3OS
Molecular weight
373.8 g/mol
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-(2-isothiocyanatoethyl)-3H-1,4-benzodiazepin-2-one
SMILES
C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN=C=S
InChIKey
LTKSVYFAUMFQML-UHFFFAOYSA-N
XLogP
3.6
Polar surface area
77.1 Ų
H-bond donors
0
H-bond acceptors
5
Formal charge
0

via PubChem

Wikidata facts

Mass
373.04518893600005
Show 2 more facts
chemical formula
C₁₈H₁₃ClFN₃OS
canonical SMILES
C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN=C=S
Sources (3)

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Encyclopedic overview

1 sections
Contents
  • References

Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group. It is a non-competitive benzodiazepine binding site antagonist. Irazepine and other alkylating benzodiazepines, such as kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.

== References ==

Excerpted from Wikipedia’s “irazepine” article, available under the CC BY-SA 4.0 licence.

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