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Difludiazepam
Sign in to saveDifludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.
Chemical data
- Formula
- C16H11ClF2N2O
- Molecular weight
- 320.72 g/mol
- IUPAC name
- 7-chloro-5-(2,6-difluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3F)F
- InChIKey
- DUNFPASORLTEGN-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 320.05279709200005
Show 3 more facts
- Commons category
- Difludiazepam
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3F)F
- chemical formula
- C₁₆H₁₁ClF₂N₂O
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- See also
- References
Difludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.
== See also == Diclazepam Flubromazepam Ro07-3953 Ro07-5220 SH-I-048A
Excerpted from Wikipedia’s “Difludiazepam” article, available under the CC BY-SA 4.0 licence.