Structure via PubChem · Public domain (PubChem)
temazepam
Sign in to saveAlso known as RER603, Restoril®, WY-3917, Restoril (TN)
Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hypnotic and anxiolytic effects begin in less than 30 minutes and can last for up to eight hours. Prescriptions for hypnotics, such as temazepam, have seen a dramatic decrease since 2010, while anxiolytics, such as alprazolam, clonazepam, and lorazepam, have increased or remained stable. Temazepam and similar hypnotics, such as triazolam (Halcion), are genera
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 419678897
- Drug.image
- Temazepam.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 218
- Drug.image2
- Temazepam-from-xtal-Mercury-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 189
- Drug.tradename
- Restoril, Normison, Nortem, others
- Drug.MedlinePlus
- a684003
- Drug.DailyMedID
- Temazepam
- Drug.pregnancy_AU
- C
- Drug.dependency_liability
- High
- Drug.routes_of_administration
- By mouth
- Drug.class
- Benzodiazepine
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- CD07
via Wikipedia infobox
Chemical data
- Formula
- C16H13ClN2O2
- Molecular weight
- 300.74 g/mol
- IUPAC name
- 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3
- InChIKey
- SEQDDYPDSLOBDC-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 52.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
1,211 papers- Temazepam.IARC monographs on the evaluation of carcinogenic risks to humans · 1996
- Temazepam (Restoril, Sandoz Pharmaceuticals).Drug intelligence & clinical pharmacy · 1982
- Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial.Journal of palliative medicine · 2024
- Temazepam: a review of its pharmacological properties and therapeutic efficacy as an hypnotic.Drugs · 1981
- Temazepam: pharmacological profile of a benzodiazepine and new trends in its clinical application.Pharmacological research · 1993
via PubMed
Wikidata facts
- Mass
- 300.067
Show 6 more facts
- chemical formula
- C₁₆H₁₃ClN₂O₂
- World Health Organisation international non-proprietary name
- temazepam
- canonical SMILES
- CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3
- Commons category
- Temazepam
- defined daily dose
- 20
- MCN code
- 2933.91.81
Sources (7)
via Wikidata · CC0
~29 min read
Article
28 sectionsContents
- Medical uses
- Contraindications
- Special caution needed
- Misuse and dependence
- Adverse effects
- Common
- Less common
- Tolerance
- Physical dependence
- Interactions
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Recreational use
- North America
- Australia
- United Kingdom
- Medical research issues
- Street terms
- Legal status
- Brand names
- References
- External links
Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hypnotic and anxiolytic effects begin in less than 30 minutes and can last for up to eight hours. Prescriptions for hypnotics, such as temazepam, have seen a dramatic decrease since 2010, while anxiolytics, such as alprazolam, clonazepam, and lorazepam, have increased or remained stable. Temazepam and similar hypnotics, such as triazolam (Halcion), are generally reserved for severe and debilitating insomnia. They have largely been replaced by z-drugs (zopiclone, zolpidem) and atypical antidepressants (trazodone, mirtazapine) as first line treatment for insomnia.
Common side effects include drowsiness, motor and cognitive impairment, lethargy, confusion, euphoria, and dizziness. Serious side effects may include hallucinations, hypotension, respiratory depression, abuse, anaphylaxis, and suicide. Use is generally not recommended together with alcohol or opioids. If the dose is rapidly decreased withdrawal may occur. Use during pregnancy or breastfeeding is not recommended. Temazepam is a short-acting benzodiazepine and hypnotic. It works by affecting GABA within the brain.