File:Lorazepam.svg · Wikimedia Commons · See Wikimedia Commons
lorazepam
Sign in to saveAlso known as Ativan®, Orfidal®, (±)-Lorazepam, Ativan, Lormetazepam, Methyllorazepam, N-Methyllorazepam, O-Chlorooxazepam
thumb|A box of Lorazepam Orion (lorazepam) tablets
Key facts
- Drug.legal_US
- Schedule IV
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 419619495
- Drug.image
- Lorazepam.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.image2
- Lorazepam ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 150
- Drug.tradename
- Ativan, others
- Drug.MedlinePlus
- a682053
- Drug.DailyMedID
- Lorazepam
- Drug.pregnancy_AU
- C
- Drug.dependency_liability
- High
- Drug.addiction_liability
- Moderate
- Drug.routes_of_administration
- By mouth, intramuscular, intravenous, transdermal
- Drug.class
- Benzodiazepine
via Wikipedia infobox
Chemical data
- Formula
- C15H10Cl2N2O2
- Molecular weight
- 321.2 g/mol
- IUPAC name
- 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
- SMILES
- C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
- InChIKey
- DIWRORZWFLOCLC-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 61.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
5,611 papersvia PubMed
Wikidata facts
- Mass
- 320.011933
Show 7 more facts
- MCN code
- 2933.91.42
- World Health Organisation international non-proprietary name
- lorazepam
- chemical formula
- C₁₅H₁₀Cl₂N₂O₂
- canonical SMILES
- C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
- Commons category
- Lorazepam
- stylized name
- LORazepam
- defined daily dose
- 2.5
Sources (10)
via Wikidata · CC0
~31 min read
Article
24 sectionsContents
- Medical uses
- Anxiety
- Seizures
- Sedation
- Agitation
- Other
- Available forms
- Adverse effects
- Contraindications
- Specific groups
- Tolerance and dependence
- Withdrawal
- Interactions
- Overdose
- Detection in body fluids
- Pharmacology
- Pharmacokinetics
- Pharmacodynamics
- History
- Society and culture
- Recreational use
- Legal status
- References
- External links
thumb|A box of Lorazepam Orion (lorazepam) tablets
Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety (including anxiety disorders), insomnia, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. It is also used during surgery to interfere with memory formation, to sedate those who are being mechanically ventilated, and, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given orally (by mouth), transdermally (on the skin via a topical gel or patch), intravenously (injection into a vein), or intramuscularly (injection into a muscle). When given by injection, onset of effects is between one and thirty minutes and effects last for up to a day.