Structure via PubChem · Public domain (PubChem)
Ro-15-4513
Sign in to saveAlso known as Ro-154513
Ro15-4513 is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s. It acts as an inverse agonist (which acts in a similar way as a competitive antagonist). The drug has been explored as possible antidote to the sedative and cognitively impairing effects of ethanol.
In the Vinony graph
Vinony's link graph records 368 inbound references to Ro-15-4513, and connects out to GABAA receptor, picrotoxin and tetrahydrodeoxycorticosterone.
It sits within the topics Antidotes, Carboxylate esters and Chemical pages without DrugBank identifier.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C15H14N6O3
- Molecular weight
- 326.31 g/mol
- IUPAC name
- ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- SMILES
- CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)N=[N+]=[N-])C
- InChIKey
- CFSOJZTUTOQNIA-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 78.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
467 papers- RO 15-4513 and its interaction with ethanol.Advances in alcohol & substance abuse · 1988
- Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.Frontiers in neuroscience · 2011
- The effects of Ro 15-4513 on the behavioral actions of ethanol in an operant reaction time task and a conflict test.Pharmacology, biochemistry, and behavior · 1988
- Cerebellar GABAA receptors and alcohol-related behaviors: focus on diazepam-insensitive [3H]Ro 15-4513 binding.Advances in biochemical psychopharmacology · 1992
- Ro 15-4513 binding to GABAA receptors: subunit composition determines ligand efficacy.Pharmacology, biochemistry, and behavior · 1992
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 326.112738
Show 3 more facts
- chemical formula
- C₁₅H₁₄N₆O₃
- canonical SMILES
- CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)N=[N+]=[N-])C
- Commons category
- Ro15-4513
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Uses
- Photoaffinity label
- Alcohol antidote
- Current use in PET Imaging
- See also
- References
Ro15-4513 is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s. It acts as an inverse agonist (which acts in a similar way as a competitive antagonist). The drug has been explored as possible antidote to the sedative and cognitively impairing effects of ethanol.
Ro15-4513 is structurally related to the benzodiazepine antidote flumazenil.
Excerpted from Wikipedia’s “Ro-15-4513” article, available under the CC BY-SA 4.0 licence.