flumazenil
Also known as flumazepil
thumb|A vial of flumazenil solution for injection
Chemical data
- Formula
- C15H14FN3O3
- Molecular weight
- 303.29 g/mol
- IUPAC name
- ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- SMILES
- CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
- InChIKey
- OFBIFZUFASYYRE-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 64.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
5,183 papersArticle
8 sectionsContents
- Medical uses
- PET radioligand
- Treatment for benzodiazepine dependence & tolerance
- Pharmacology
- Pharmacodynamics
- Availability
- References
- External links
thumb|A vial of flumazenil solution for injection
Flumazenil, also known as flumazepil, is a selective GABAA receptor antagonist administered via injection, or intranasally. Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition.
Gallery (5)
Connections
Categories
AntidotesAnxiogenicsCarboxylate estersChemical substances for emergency medicineConvulsantsDrugboxes which contain changes to watched fieldsDrugs developed by Hoffmann-La RocheDrugs with non-standard legal statusECHA InfoCard ID from WikidataFluoroarenesGABAA receptor negative allosteric modulatorsImidazobenzodiazepines