Structure via PubChem · Public domain (PubChem)
suritozole
Sign in to saveSuritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABAA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM. It was investigated for the treatment of depression and Alzheimer's disease in the 90s, but clinical development seems to have been discontinued.
In the Vinony graph
Vinony's link graph records 195 inbound references to suritozole, and connects out to GABAA receptor, picrotoxin and tetrahydrodeoxycorticosterone.
It sits within the topics 3-Fluorophenyl compounds, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C10H10FN3S
- Molecular weight
- 223.27 g/mol
- IUPAC name
- 5-(3-fluorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione
- SMILES
- CN1C(=NN(C1=S)C)C2=CC(=CC=C2)F
- InChIKey
- IWDUZEHNLHFBRZ-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 50.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 223.058
Show 3 more facts
- chemical formula
- C₁₀H₁₀FN₃S
- canonical SMILES
- CN1C(=NN(C1=S)C)C2=CC(=CC=C2)F
- subject has role
- nootropic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABAA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM. It was investigated for the treatment of depression and Alzheimer's disease in the 90s, but clinical development seems to have been discontinued.
==Synthesis== class=skin-invert-image|thumb|center|500px|Synthesis: ~85%: Patents: etc
Excerpted from Wikipedia’s “suritozole” article, available under the CC BY-SA 4.0 licence.