prasterone
Sign in to saveAlso known as dehydroepiandrosterone
Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for childbirth, among other uses. It is taken by mouth, by application to the skin, in through the vagina, or by injection into muscle.
Clinical Trials
90 registered- PHASE4ENROLLING_BY_INVITATIONCombination Osilodrostat and Cabergoline in Cushing's DiseaseUniversity of Basrah · NCT07603466
- COMPLETEDHormonal Status and Quality of Life in Female Postmenopausal Patients With Burning Mouth SyndromeUniversity of Zagreb · NCT04535973
- PHASE3COMPLETEDPrasterone (DHEA) for the Treatment of Hypoactive Sexual Desire Disorder (HSDD)EndoCeutics Inc. · NCT03287232
- COMPLETEDEpidemiology of Insulin and Dehydroepiandrosterone Sulfate and Coronary Heart Disease MortalityNational Heart, Lung, and Blood Institute (NHLBI) · NCT00005246
- PHASE3SUSPENDEDSafety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum MalariaUniversité Victor Segalen Bordeaux 2 · NCT00442403
- PHASE2/PHASE3RECRUITINGGrowth Hormone and Dehydroepiandrosterone Role in Vitro FertilizationBeni-Suef University · NCT07323329
~21 min read
Article
35 sectionsContents
- Medical uses
- Deficiency
- Menopause
- Vaginal atrophy
- Sexual desire
- Childbirth
- Available forms
- Side effects
- Pharmacokinetics
- Metabolism
- Dose-response of hormone levels
- Dosing
- Chemistry
- Derivatives
- History
- Society and culture
- Generic names
- Marketing
- Regulation
- By country
- Australia
- Canada
- United Kingdom
- United States
- Sports and athletics
- Research
- Anabolic uses
- Cancer
- Cardiovascular disease
- Lupus
- Memory
- Mood
- See also
- References
- Further reading
Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for childbirth, among other uses. It is taken by mouth, by application to the skin, in through the vagina, or by injection into muscle.
Side effects of prasterone in women include symptoms of masculinization like oily skin, acne, increased hair growth, voice changes, and increased sexual desire, headaches, insomnia, and others. The compound is a naturally occurring prohormone of androgens and estrogens and hence is an agonist of the androgen and estrogen receptors, the respective biological targets of androgens like testosterone and estrogens like estradiol. Prasterone also has a variety of activities of its own, including neurosteroid and other activities.