ESR2

Also known as ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor 2, ODG8

protein-coding gene in the species Homo sapiens

Gene data

ESR2

Name: estrogen receptor 2
Type: protein-coding
Position: 64,084,232–64,338,112 (−)
Aliases: ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8
Ensembl: ENSG00000140009
RefSeq RNA: NM_001040275.1, NM_001040276.1, NM_001214902.1, NM_001214903.1, NM_001271876.1
RefSeq protein: NP_001035365.1, NP_001201831.1, NP_001258805.1, NP_001258806.1, NP_001278641.1

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].