(-)-equol
Sign in to saveAlso known as (S)-(-)-4',7-Isoflavandiol, (-)-(S)-Equol, 4',7-Isoflavandiol, (S)-Equol, 4',7-Dihydroxyisoflavan, (S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-Benzopyran-7-ol, S-equol
Equol (4',7-isoflavandiol) is an isoflavandiol estrogen metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines. While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. Only about 30–50% of people have intestinal bacteria that make equol.
Research
1,451 papers- Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum.Gut microbes · 2024
- Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial.International journal of molecular sciences · 2023
- Equol: pharmacokinetics and biological actions.The Journal of nutrition · 2010
- Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects.Nutrients · 2019
- Equol: history, chemistry, and formation.The Journal of nutrition · 2010
via PubMed
Wikidata facts
- Mass
- 242.094294
Show 4 more facts
- chemical formula
- C₁₅H₁₄O₃
- canonical SMILES
- C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O
- isomeric SMILES
- OC1=CC=C(C=C1)[C@H]2COC3=C(C2)C=CC(O)=C3
- NCI Thesaurus ID
- C120313
via Wikidata · CC0
~7 min read
Article
12 sectionsContents
- History
- Chemical structure
- Pharmacology
- Estrogen receptor binding
- Pharmacokinetics
- Production in humans
- Equol producing bacteria
- Health effects
- Skin health
- Hormone-related health effects
- See also
- References
Equol (4',7-isoflavandiol) is an isoflavandiol estrogen metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines. While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. Only about 30–50% of people have intestinal bacteria that make equol.
== History == (S)-Equol was first isolated from horse urine in 1932, and the name was suggested by this equine connection. Since then, equol has been found in the urine or plasma of many other animal species, although these animals have significant differences in their ability to metabolize daidzein into equol. In 1980, scientists reported the discovery of equol in humans. The ability of (S)-equol to play a role in the treatment of estrogen- or androgen-mediated diseases or disorders was first proposed in 1984.