HOPX
Sign in to saveAlso known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO
Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells.
Gene data
HOPX- Name
- HOP homeobox
- Type
- protein-coding
- Position
- 56,647,195–56,681,877 (−)
- Aliases
- CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO
- Ensembl
- ENSG00000171476
- RefSeq RNA
- NM_001145459.2, NM_001145460.2, NM_001438047.1, NM_032495.6, NM_139211.5
- RefSeq protein
- NP_001138931.1, NP_001138932.1, NP_001424976.1, NP_115884.4, NP_631957.1
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
HOP homeobox
- Symbol
- HOPX
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:56,647,195-56,681,877
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells.
== Function == The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.
Excerpted from Wikipedia’s “HOPX” article, available under the CC BY-SA 4.0 licence.