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GeneQ17917643· pop 7· linked from 881 articles

ETS2

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Also known as ETS2IT1, ETS proto-oncogene 2, transcription factor

ETS2 is a gene that in humans is encoding the C-ETS2 protein. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.

Gene data

ETS2

Name: ETS proto-oncogene 2, transcription factor
Type: protein-coding
Position: 38,805,115–38,824,956 (+)
Aliases: ETS2IT1
Ensembl: ENSG00000157557
RefSeq RNA: NM_001256295.2, NM_005239.6, XM_005260935.2, XM_017028290.2, XM_054324370.1
RefSeq protein: NP_001243224.1, NP_005230.1, XP_005260992.1, XP_016883779.1, XP_054180345.1

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II skeletal system development regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Ras signaling pathway - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Cellular responses to stress Cellular Senescence Oncogene Induced Senescence Cellular responses to stimuli Myometrial relaxation and contraction pathways Ras signaling Extracellular vesicles in the crosstalk of cardiac cells

via MyGene.info

Gene · Ensembl

ETS proto-oncogene 2, transcription factor

Symbol: ETS2
Biotype: Protein coding
Organism: Homo sapiens
Location: 21:38,805,115-38,824,956
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ETS2 PDB 1k78.png

Show 5 more facts

HomoloGene ID: 3838
exact match: identifiers.org/ncbigene/2114
genomic end: 40196879
genomic start: 38805183
cytogenetic location: 21q22.2

Sources (3)

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Article

5 sections

Contents

Interactions
Clinical significance
References
Further reading
External links

ETS2 is a gene that in humans is encoding the C-ETS2 protein. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.

== Interactions ==

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 21 Transcription factors