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GeneQ18030124· pop 7· linked from 819 articles

NFYB

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Also known as CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

In the Vinony graph

Within Vinony's link graph, NFYB is referenced by 819 other articles, and connects out to Q180686, human chromosome 12 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 12 and Transcription factors.

Its subject is documented across 7 Wikipedia language editions.

Gene data

NFYB

Name: nuclear transcription factor Y subunit beta
Type: protein-coding
Position: 104,117,080–104,138,293 (−)
Aliases: CBF-A, CBF-B, HAP3, NF-YB
Ensembl: ENSG00000120837
RefSeq RNA: NM_001414518.1, NM_001414519.1, NM_001414520.1, NM_001414521.1, NM_001414522.1
RefSeq protein: NP_001401447.1, NP_001401448.1, NP_001401449.1, NP_001401450.1, NP_001401451.1

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex CCAAT-binding factor complex CCAAT-binding factor complex

Pathways

Antigen processing and presentation - Homo sapiens (human)Tuberculosis - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Metabolism Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Regulation of cholesterol biosynthesis by SREBP (SREBF)PPARA activates gene expression Generic Transcription Pathway Cellular responses to stress

via MyGene.info

Gene · Ensembl

nuclear transcription factor Y subunit beta

Symbol: NFYB
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:104,117,080-104,138,293
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein NFYB PDB 1n1j.png

Show 5 more facts

HomoloGene ID: 38149
exact match: identifiers.org/ncbigene/4801
genomic end: 104138241
genomic start: 104117086
cytogenetic location: 12q23.3

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

== Function ==

Excerpted from Wikipedia’s “NFYB” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 12 Transcription factors