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GeneQ18030124· pop 7· linked from 819 articles

NFYB

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Also known as CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Gene data

NFYB

Name: nuclear transcription factor Y subunit beta
Type: protein-coding
Position: 104,117,080–104,138,241 (−)
Aliases: CBF-A, CBF-B, HAP3, NF-YB
Ensembl: ENSG00000120837
RefSeq RNA: NM_001414518.1, NM_001414519.1, NM_001414520.1, NM_001414521.1, NM_001414522.1
RefSeq protein: NP_001401447.1, NP_001401448.1, NP_001401449.1, NP_001401450.1, NP_001401451.1

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex CCAAT-binding factor complex CCAAT-binding factor complex

Pathways

Antigen processing and presentation - Homo sapiens (human)Tuberculosis - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Metabolism Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Regulation of cholesterol biosynthesis by SREBP (SREBF)PPARA activates gene expression Generic Transcription Pathway Cellular responses to stress

via MyGene.info

Gene · Ensembl

nuclear transcription factor Y subunit beta

Symbol: NFYB
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:104,117,080-104,138,293
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein NFYB PDB 1n1j.png

Show 5 more facts

HomoloGene ID: 38149
exact match: identifiers.org/ncbigene/4801
genomic end: 104138241
genomic start: 104117086
cytogenetic location: 12q23.3

Sources (3)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

== Function ==

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Categories

Genes on human chromosome 12 Transcription factors