RBPJ

Name

recombination signal binding protein for immunoglobulin kappa J region

Type

protein-coding

Aliases

AOS3, CBF-1, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBP-J kappa, RBP-JK, RBPJK

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].

via MyGene.info

Gene · Ensembl

recombination signal binding protein for immunoglobulin kappa J region

Symbol

RBPJ

Biotype

Protein coding

Organism

Homo sapiens

Location

4:26,163,455-26,435,131

Strand

Forward (+)

Assembly

GRCh38

• Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.Advances in experimental medicine and biology · 2021
• TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the Notch signaling pathway.Cell death & disease · 2024
• Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease.Immunity · 2024
• Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer.Theranostics · 2025
• Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice.Hepatology communications · 2025

via PubMed

Wikidata facts

Image

Protein RBPJ PDB 2f8x.png

via Wikidata · CC0