KAT2B

Also known as CAF, P/CAF, PCAF, lysine acetyltransferase 2B

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

Gene data

KAT2B

Name: lysine acetyltransferase 2B
Type: protein-coding
Position: 20,040,400–20,154,404 (+)
Aliases: CAF, P/CAF, PCAF
Ensembl: ENSG00000114166
RefSeq RNA: NM_003884.5, XM_005265528.5, XM_047449147.1, XM_054348277.1, XM_054348278.1
RefSeq protein: NP_003875.3, XP_005265585.1, XP_047305103.1, XP_054204252.1, XP_054204253.1

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008].

Pathways

Notch signaling pathway - Homo sapiens (human)Thyroid hormone signaling pathway - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Developmental Biology Signaling by NOTCH Signaling by NOTCH Signal Transduction Signal Transduction Disease

via MyGene.info

Gene · Ensembl

lysine acetyltransferase 2B

Symbol: KAT2B
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:20,040,055-20,154,405
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Research

205 papers

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.Nature communications · 2023
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients.Journal of translational medicine · 2025
KAT2A and KAT2B prevent double-stranded RNA accumulation and interferon signaling to maintain intestinal stem cell renewal.Science advances · 2024
Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Acetylation in the regulation of autophagy.Autophagy · 2023

via PubMed

Wikidata facts

Image: Protein PCAF PDB 1cm0.png

Show 5 more facts

HomoloGene ID: 20834
exact match: identifiers.org/ncbigene/8850
genomic end: 20195896
genomic start: 20040446
cytogenetic location: 3p24.3

Sources (8)

via Wikidata · CC0

~2 min read

Article

10 sections

Contents

Structure
Function
Regulation
Protein interactions
Targets
Interactions
See also
References
External links
Further reading

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

==Structure== Several domains of PCAF can act independently or in unison to enable its functions. PCAF has separate acetyltransferase and E3 ubiquitin ligase domains as well as a bromodomain for interaction with other proteins. PCAF also possesses sites for its own acetylation and ubiquitination.