KAT2B

Also known as CAF, P/CAF, PCAF, lysine acetyltransferase 2B

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

Gene data

KAT2B

Name: lysine acetyltransferase 2B
Type: protein-coding
Position: 20,040,400–20,154,404 (+)
Aliases: CAF, P/CAF, PCAF
Ensembl: ENSG00000114166
RefSeq RNA: NM_003884.5, XM_005265528.5, XM_047449147.1, XM_054348277.1, XM_054348278.1
RefSeq protein: NP_003875.3, XP_005265585.1, XP_047305103.1, XP_054204252.1, XP_054204253.1

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

Article

10 sections

Contents

Structure
Function
Regulation
Protein interactions
Targets
Interactions
See also
References
External links
Further reading

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

==Structure== Several domains of PCAF can act independently or in unison to enable its functions. PCAF has separate acetyltransferase and E3 ubiquitin ligase domains as well as a bromodomain for interaction with other proteins. PCAF also possesses sites for its own acetylation and ubiquitination.