USF1
Sign in to saveAlso known as FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11, upstream transcription factor 1
Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.
Gene data
USF1- Name
- upstream transcription factor 1
- Type
- protein-coding
- Aliases
- FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013].
via MyGene.info
Gene · Ensembl
upstream transcription factor 1
- Symbol
- USF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:161,039,249-161,045,982
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein USF1 PDB 1an4.png
Show 5 more facts
- HomoloGene ID
- 31426
- genomic end
- 161015767
- exact match
- identifiers.org/ncbigene/7391
- genomic start
- 161009041
- cytogenetic location
- 1q23.3
Sources (3)
via Wikidata · CC0
~19 min read
Article
22 sectionsContents
- Gene
- Isoforms
- Protein
- Function
- Regulation
- Modulation of DNA binding affinity
- Phosphorylation
- Gene transcription
- Chromosome boundary by USF
- FASN transactivates for lipogenesis
- Lipogenic pathways
- In early embryonic development
- Clinical significance
- Diabetic kidney disease
- Cancer
- Increased FASN-mediated de novo lipid synthesis
- Decreased USF1-p53 interaction and increased p53 instability
- Familial combined hyperlipidemia
- Interactions
- References
- Further reading
- External links
Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.
== Gene == left|thumb|Representative illustration of bHLH motif binding to the consensus sequence on DNA