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GeneQ18027185· pop 5· linked from 815 articles

HOXC6

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Also known as CP25, HHO.C8, HOX3, HOX3C, homeobox C6

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

Gene data

HOXC6
Name
homeobox C6
Type
protein-coding
Position
53,990,624–54,030,823 (+)
Aliases
CP25, HHO.C8, HOX3, HOX3C
Ensembl
ENSG00000197757
RefSeq RNA
NM_004503.4, NM_153693.5
RefSeq protein
NP_004494.1, NP_710160.1

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008].

Gene Ontology

via MyGene.info

Gene · Ensembl

homeobox C6

Symbol
HOXC6
Biotype
Protein coding
Organism
Homo sapiens
Location
12:53,990,624-54,030,823
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Knock-out model
  • See also
  • References
  • Further reading
  • External links

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

== Function ==

Excerpted from Wikipedia’s “HOXC6” article, available under the CC BY-SA 4.0 licence.

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