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GeneQ18036453· pop 7· linked from 813 articles

KLF12

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Also known as AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Gene data

KLF12
Name
KLF transcription factor 12
Type
protein-coding
Position
73,686,022–74,168,331 (−)
Aliases
AP-2rep, AP2REP, HSPC122
Ensembl
ENSG00000118922
RefSeq RNA
NM_001400136.1, NM_001400139.1, NM_001400141.1, NM_001400146.1, NM_001400147.1
RefSeq protein
NP_001387065.1, NP_001387068.1, NP_001387070.1, NP_001387075.1, NP_001387076.1

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Cellular component

chromatinnucleusnucleus

via MyGene.info

Gene · Ensembl

KLF transcription factor 12

Symbol
KLF12
Biotype
Protein coding
Organism
Homo sapiens
Location
13:73,686,022-74,168,331
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • See also
  • References
  • Further reading
  • External links

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “KLF12” article, available under the CC BY-SA 4.0 licence.

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