FOSL1
Sign in to saveAlso known as FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Gene data
FOSL1- Name
- FOS like 1, AP-1 transcription factor subunit
- Type
- protein-coding
- Position
- 65,892,049–65,900,573 (−)
- Aliases
- FRA, FRA1, fra-1
- Ensembl
- ENSG00000175592
- RefSeq RNA
- NM_001300844.2, NM_001300855.2, NM_001300856.2, NM_001300857.2, NM_005438.5
- RefSeq protein
- NP_001287773.1, NP_001287784.1, NP_001287785.1, NP_001287786.1, NP_005429.1
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
FOS like 1, AP-1 transcription factor subunit
- Symbol
- FOSL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,892,049-65,900,573
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
589 papers- FOSL1's Oncogene Roles in Glioma/Glioma Stem Cells and Tumorigenesis: A Comprehensive Review.International journal of molecular sciences · 2024
- CYTOR Facilitates Formation of FOSL1 Phase Separation and Super Enhancers to Drive Metastasis of Tumor Budding Cells in Head and Neck Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
- FOSL1: The core regulatory hub of tumor-neural interactions and its clinical translational prospects.International immunopharmacology · 2025
- Spatiotemporal single-cell roadmap of human skin wound healing.Cell stem cell · 2025
- Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis.International journal of molecular sciences · 2022
via PubMed
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
== Function == The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Excerpted from Wikipedia’s “FOSL1” article, available under the CC BY-SA 4.0 licence.