FOSL1
Sign in to saveAlso known as FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Gene data
FOSL1- Name
- FOS like 1, AP-1 transcription factor subunit
- Type
- protein-coding
- Aliases
- FRA, FRA1, fra-1
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
via MyGene.info
Gene · Ensembl
FOS like 1, AP-1 transcription factor subunit
- Symbol
- FOSL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,892,049-65,900,573
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
589 papers- FOSL1's Oncogene Roles in Glioma/Glioma Stem Cells and Tumorigenesis: A Comprehensive Review.International journal of molecular sciences · 2024
- CYTOR Facilitates Formation of FOSL1 Phase Separation and Super Enhancers to Drive Metastasis of Tumor Budding Cells in Head and Neck Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
- FOSL1: The core regulatory hub of tumor-neural interactions and its clinical translational prospects.International immunopharmacology · 2025
- Spatiotemporal single-cell roadmap of human skin wound healing.Cell stem cell · 2025
- Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis.International journal of molecular sciences · 2022
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3967
- exact match
- identifiers.org/ncbigene/8061
- genomic end
- 65668044
- genomic start
- 65659520
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
== Function == The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.