FOSB

Also known as AP-1, G0S3, GOS3, GOSB, ΔFosB, FosB proto-oncogene, AP-1 transcription factor subunit

Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene.

Gene data

FOSB

Name: FosB proto-oncogene, AP-1 transcription factor subunit
Type: protein-coding
Position: 45,467,995–45,475,179 (+)
Aliases: AP-1, G0S3, GOS3, GOSB
Ensembl: ENSG00000125740
RefSeq RNA: NM_001114171.2, NM_001411069.1, NM_006732.3, XM_047438550.1, XM_054320409.1
RefSeq protein: NP_001107643.1, NP_001397998.1, NP_006723.2, XP_047294506.1, XP_054176384.1

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways

Osteoclast differentiation - Homo sapiens (human)IL-17 signaling pathway - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Amphetamine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)Adaptive Immune System Signal Transduction Signal Transduction Signaling by NTRKs Signaling by NTRKs

via MyGene.info

Gene · Ensembl

FosB proto-oncogene, AP-1 transcription factor subunit

Symbol: FOSB
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:45,467,989-45,475,179
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 31403
exact match: identifiers.org/ncbigene/2354
genomic end: 45978437
genomic start: 45971253
cytogenetic location: 19q13.32

Sources (5)

via Wikidata · CC0

~11 min read

Article

10 sections

Contents

{{anchor|Delta FosB}}DeltaFosB
Role in addiction
Plasticity in cocaine addiction
Summary of addiction-related plasticity
Other functions in the brain
See also
Notes
References
Further reading
External links

Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene.

The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a known transactivation domain, in turn preventing it from affecting transcription through the AP-1 complex.