EHMT2
Sign in to saveAlso known as BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a deposits the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and H3K27me2). The presence of H3K9me1/2 is usually associated with gene silencing.
Gene data
EHMT2- Name
- euchromatic histone lysine methyltransferase 2
- Type
- protein-coding
- Position
- 31,879,758–31,897,723 (−)
- Aliases
- BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
- Ensembl
- ENSG00000224143
- RefSeq RNA
- NM_001289413.2, NM_001318833.2, NM_001363689.2, NM_001395160.1, NM_001395161.1
- RefSeq protein
- NP_001276342.1, NP_001305762.1, NP_001350618.1, NP_001382089.1, NP_001382090.1
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
euchromatic histone lysine methyltransferase 2
- Symbol
- EHMT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MCF_CTG1:3,221,824-3,239,759
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein EHMT2 PDB 2o8j.png
Show 5 more facts
- HomoloGene ID
- 48460
- exact match
- identifiers.org/ncbigene/10919
- genomic start
- 31847536
- genomic end
- 31865464
- cytogenetic location
- 6p21.33
Sources (4)
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Function
- Interactions
- EHMT2 in cancer
- References
- Further reading
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a deposits the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and H3K27me2). The presence of H3K9me1/2 is usually associated with gene silencing.
== Function ==