EHMT1
Sign in to saveAlso known as EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1
Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.
In the Vinony graph
Vinony's link graph records 66 inbound references to EHMT1, and connects out to transferase, PubMed and Ensembl genome database project.
Vinony files it under EC 2.1.1 and Genes on human chromosome 9.
Vinony links it to 6 Wikipedia language editions.
Gene data
EHMT1- Name
- euchromatic histone lysine methyltransferase 1
- Type
- protein-coding
- Position
- 137,618,901–137,870,016 (+)
- Aliases
- EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D
- Ensembl
- ENSG00000181090
- RefSeq RNA
- NM_001039765.1, NM_001145527.2, NM_001354259.2, NM_001354263.2, NM_001354611.2
- RefSeq protein
- NP_001138999.1, NP_001341188.1, NP_001341192.1, NP_001341540.1, NP_001341541.1
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
euchromatic histone lysine methyltransferase 1
- Symbol
- EHMT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:137,618,901-137,870,016
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 11698
- exact match
- identifiers.org/ncbigene/79813
- cytogenetic location
- 9q34.3
- genomic end
- 140764468
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 9
- genomic start
- 137618992
- genetic association
- Kleefstra syndrome
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Function
- Clinical significance
- References
- External links
Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.
== Structure ==
Excerpted from Wikipedia’s “EHMT1” article, available under the CC BY-SA 4.0 licence.