PCMT1
Sign in to saveAlso known as PIMT, protein-L-isoaspartate (D-aspartate) O-methyltransferase
Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.
Gene data
PCMT1- Name
- protein-L-isoaspartate (D-aspartate) O-methyltransferase
- Type
- protein-coding
- Position
- 149,749,197–149,811,422 (+)
- Aliases
- PIMT
- Ensembl
- ENSG00000120265
- RefSeq RNA
- NM_001252049.1, NM_001252050.1, NM_001252051.1, NM_001252052.1, NM_001252053.1
- RefSeq protein
- NP_001238978.1, NP_001238979.1, NP_001238980.1, NP_001238981.1, NP_001238982.1
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
protein-L-isoaspartate (D-aspartate) O-methyltransferase
- Symbol
- PCMT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:149,749,197-149,811,422
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PCMT1 PDB 1i1n.png
Show 7 more facts
- HomoloGene ID
- 55895
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5110
- genomic end
- 150132556
- genomic start
- 150070579
- chromosome
- human chromosome 6
- cytogenetic location
- 6q25.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]
Excerpted from Wikipedia’s “PCMT1” article, available under the CC BY-SA 4.0 licence.