MGAT1

Also known as GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to MGAT1, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 5 Wikipedia language editions.

Gene data

MGAT1

Name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Type: protein-coding
Position: 180,784,780–180,815,652 (−)
Aliases: GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI, MGAT
Ensembl: ENSG00000131446
RefSeq RNA: NM_001114617.2, NM_001114618.1, NM_001114619.1, NM_001114620.1, NM_001364377.2
RefSeq protein: NP_001108089.1, NP_001108090.1, NP_001108091.1, NP_001108092.1, NP_001351306.1

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

protein N-linked glycosylation protein N-linked glycosylation glycoprotein biosynthetic process viral protein processing

Molecular function

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity protein binding acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity

Cellular component

Golgi membrane Golgi membrane Golgi apparatus membrane endoplasmic reticulum-Golgi intermediate compartment membrane perinuclear region of cytoplasm extracellular exosome extracellular vesicle

Pathways

N-Glycan biosynthesis - Homo sapiens (human)Various types of N-glycan biosynthesis - Homo sapiens (human)Disease Metabolism of proteins Asparagine N-linked glycosylation Infectious disease Post-translational protein modification Transport to the Golgi and subsequent modification N-glycan trimming and elongation in the cis-Golgi SARS-CoV-1 Infection

via MyGene.info

Gene · Ensembl

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Symbol: MGAT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:180,784,780-180,815,652
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MGAT1 PDB 1fo8.png

Show 7 more facts

HomoloGene ID: 1804
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4245
genomic end: 180242652
genomic start: 180217541
chromosome: human chromosome 5
cytogenetic location: 5q35.3

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.

There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.

Excerpted from Wikipedia’s “MGAT1” article, available under the CC BY-SA 4.0 licence.