MGAM

Also known as MG, MGA, Maltase-glucoamylase

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.

In the Vinony graph

Within Vinony's link graph, MGAM is referenced by 323 other articles, and connects out to PubMed, Ensembl genome database project and Wikidata.

It sits within the topics Genes on human chromosome 7 and Human proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MGAM

Name: maltase-glucoamylase
Type: protein-coding
Position: 141,907,813–142,106,747 (+)
Aliases: MG, MGA
Ensembl: ENSG00000282607
RefSeq RNA: NM_001365693.1, NM_004668.3, XM_011516670.3, XM_011516671.3, XM_011516672.3
RefSeq protein: NP_001352622.1, NP_004659.2, XP_011514972.1, XP_011514973.1, XP_011514974.1

This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008].

Pathways

Galactose metabolism - Homo sapiens (human)Starch and sucrose metabolism - Homo sapiens (human)Carbohydrate digestion and absorption - Homo sapiens (human)Innate Immune System Immune System Digestion of dietary carbohydrate Neutrophil degranulation Digestion Digestion and absorption Glucocorticoid Receptor Pathway

via MyGene.info

Gene · Ensembl

maltase-glucoamylase

Symbol: MGAM
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:141,907,813-142,106,747
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 2qly EBI.png

Show 8 more facts

HomoloGene ID: 130099
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8972
cytogenetic location: 7q34
chromosome: human chromosome 7
genomic start: 141607613
genomic end: 141806547
expressed in: renal cortex

Sources (3)

via Wikidata · CC0

~4 min read

Encyclopedic overview

10 sections

Contents

Gene
Tissue distribution
Enzymatic mechanism
Structure
N-terminal maltase
C-terminal glucase
See also
References
Further reading
External links

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.

Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers. In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.

Excerpted from Wikipedia’s “MGAM” article, available under the CC BY-SA 4.0 licence.