MGAM

Also known as MG, MGA, Maltase-glucoamylase

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.

Gene data

MGAM

Name: maltase-glucoamylase
Type: protein-coding
Aliases: MG, MGA

This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

maltase-glucoamylase

Symbol: MGAM
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:141,907,813-142,106,747
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 2qly EBI.png

Show 5 more facts

HomoloGene ID: 130099
exact match: identifiers.org/ncbigene/8972
cytogenetic location: 7q34
genomic start: 141607613
genomic end: 141806547

Sources (3)

via Wikidata · CC0

~4 min read

Article

10 sections

Contents

Gene
Tissue distribution
Enzymatic mechanism
Structure
N-terminal maltase
C-terminal glucase
See also
References
Further reading
External links

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.

Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers. In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.