Also known as hTDG, Thymine-DNA glycosylase, thymine DNA glycosylase
protein-coding gene in the species Homo sapiens
Gene data
TDG- Name
- thymine DNA glycosylase
- Type
- protein-coding
- Position
- 103,965,799–103,988,874 (+)
- Aliases
- hTDG
- Ensembl
- ENSG00000139372
- RefSeq RNA
- NM_001008411.1, NM_001363612.2, NM_003211.6, XM_047429486.1, XM_047429487.1
- RefSeq protein
- NP_001350541.1, NP_003202.3, XP_047285442.1, XP_047285443.1, XP_047285444.1
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
thymine DNA glycosylase
- Symbol
- TDG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:103,965,799-103,988,874
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TDG PDB 1wyw.png
Show 5 more facts
- HomoloGene ID
- 2415
- exact match
- identifiers.org/ncbigene/6996
- genomic end
- 104382652
- genomic start
- 103965822
- cytogenetic location
- 12q23.3
Sources (4)
via Wikidata · CC0