ABCG2
Sign in to saveAlso known as ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338
thumb|ABCG2 with simulated plasma membrane
Gene data
ABCG2- Name
- ATP binding cassette subfamily G member 2 (JR blood group)
- Type
- protein-coding
- Position
- 88,090,150–88,231,818 (−)
- Aliases
- ABC15, ABCP, BCRP, BMDP, CD338, CDw338, CDw388, EST157481, GOUT1, MRX
- Ensembl
- ENSG00000118777
- RefSeq RNA
- NM_001257386.2, NM_001348985.1, NM_001348986.2, NM_001348987.1, NM_001348988.1
- RefSeq protein
- NP_001244315.1, NP_001335914.1, NP_001335915.1, NP_001335916.1, NP_001335917.1
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ATP binding cassette subfamily G member 2 (JR blood group)
- Symbol
- ABCG2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:88,088,127-88,231,818
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55852
- genomic end
- 89152474
- cytogenetic location
- 4q22.1
- exact match
- identifiers.org/ncbigene/9429
- genomic start
- 88090150
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Function
- Interactive pathway map
- Inhibition
- See also
- References
- Further reading
- External links
thumb|ABCG2 with simulated plasma membrane
ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.