CD86 molecule
Sign in to saveAlso known as B-lymphocyte activation antigen B7-2, FUN-1, BU63, T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, CD86, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.
Protein · UniProt
T-lymphocyte activation antigen CD86
- Gene
- CD86
- Organism
- Homo sapiens (Human)
- Length
- 329 aa
- Molecular mass
- 37,682 Da
- Evidence
- 1: Evidence at protein level
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291, PubMed:7694363). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (Pub…
Swiss-Prot (reviewed) · via UniProt
Research
5,898 papers- Soluble CD86 is a costimulatory molecule for human T lymphocytes.Immunity · 2000
- The Effect of CD86 Expression on the Proliferation and the Survival of CLL Cells.Pathology oncology research : POR · 2019
- Accessory Molecule and Costimulation Requirements for CD4 T Cell Response.Critical reviews in immunology · 2017
- Association between co-stimulatory molecule gene polymorphism and acute rejection of allograft.Transplant immunology · 2014
- The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.Blood · 1994
via PubMed
Wikidata facts
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- Commons category
- CD86
- exact match
- purl.uniprot.org/uniprot/P42081
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Article
8 sectionsContents
- Structure
- Role in co-stimulation, T-cell activation and inhibition
- Treg mediation
- Role in pathology
- See also
- References
- External links
- Further reading
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.
The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.