CD86 molecule
Also known as B-lymphocyte activation antigen B7-2, FUN-1, BU63, T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, CD86, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.
Research
5,898 papers- Soluble CD86 is a costimulatory molecule for human T lymphocytes.Immunity · 2000
- The Effect of CD86 Expression on the Proliferation and the Survival of CLL Cells.Pathology oncology research : POR · 2019
- Accessory Molecule and Costimulation Requirements for CD4 T Cell Response.Critical reviews in immunology · 2017
- Association between co-stimulatory molecule gene polymorphism and acute rejection of allograft.Transplant immunology · 2014
- The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.Blood · 1994
via PubMed
Article
8 sectionsContents
- Structure
- Role in co-stimulation, T-cell activation and inhibition
- Treg mediation
- Role in pathology
- See also
- References
- External links
- Further reading
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.
The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.