abatacept
Sign in to saveAlso known as BMS-188667, RG-1046, RG-2077, CTLA4-IgG4m, CTLA4IgG4m, CTLA4Ig, CTLA4-Ig
Abatacept, sold under the brand name Orencia, is a medication used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody.
Research
5,080 papers- Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis.The New England journal of medicine · 2020
- Abatacept.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2006
- Abatacept for the treatment of rheumatoid arthritis.Expert review of clinical immunology · 2019
- Abatacept and the risk of malignancy: a meta-analysis across disease indications.Rheumatology (Oxford, England) · 2025
- [Abatacept].Nihon rinsho. Japanese journal of clinical medicine · 2016
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 92300
- Has use
- medication
Show 6 more facts
- subject has role
- immunosuppressive drug
- defined daily dose
- 27
- medical condition treated
- arthritis
- chemical formula
- C₃₄₉₈H₅₄₅₈N₉₂₂O₁₀₉₀S₃₂
- has characteristic
- biopharmaceutical
- physically interacts with
- CD86 molecule
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Chemistry
- Mechanism of action
- References
- External links
Abatacept, sold under the brand name Orencia, is a medication used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody.
Abatacept is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an antigen-presenting cell must present two signals to the T cell. One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2). Abatacept binds to the CD80 and CD86 molecule, and prevents the second signal. Without the second signal, the T cell can't be activated.
Excerpted from Wikipedia’s “abatacept” article, available under the CC BY-SA 4.0 licence.