Structure via PubChem · Public domain (PubChem)
siponimod
Sign in to saveAlso known as BAF312, Mayzent
Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis (MS). It is intended for once-daily oral administration.
Chemical data
- Formula
- C29H35F3N2O3
- Molecular weight
- 516.6 g/mol
- IUPAC name
- 1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid
- SMILES
- CCC1=C(C=CC(=C1)/C(=N/OCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)/C)CN4CC(C4)C(=O)O
- InChIKey
- KIHYPELVXPAIDH-HNSNBQBZSA-N
- XLogP
- 4.8
- Polar surface area
- 62.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2019
- Admin. routes
- oral
- Indications
- polymyositis, liver disease, relapsing-remitting multiple sclerosis, dermatomyositis
via ChEMBL · EBI
Research
370 papers- Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study.Lancet (London, England) · 2018
- Siponimod.2012
- Siponimod for multiple sclerosis.The Cochrane database of systematic reviews · 2021
- Siponimod.2006
- Siponimod to treat secondary progressive multiple sclerosis.Drugs of today (Barcelona, Spain : 1998) · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 516.26
- Manufacturer
- Novartis
- Has use
- medication
Show 5 more facts
- Commons category
- Siponimod
- canonical SMILES
- CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O
- chemical formula
- C₂₉H₃₅F₃N₂O₃
- isomeric SMILES
- CCC1=C(C=CC(=C1)/C(=N/OCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)/C)CN4CC(C4)C(=O)O
- World Health Organisation international non-proprietary name
- siponimod
Sources (5)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- Mechanism of action
- History
- References
{{Infobox drug | image = Siponimod.svg | image_class = skin-invert-image | width = 275 | alt = | caption =
| pronounce = | tradename = Mayzent | Drugs.com = | MedlinePlus = a619027 | DailyMedID = Siponimod | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = L04 | ATC_suffix = AE03 | ATC_supplemental =
Excerpted from Wikipedia’s “siponimod” article, available under the CC BY-SA 4.0 licence.