obinutuzumab
Sign in to saveAlso known as Afutuzumab, Ro-5072759 HUMAB<CD20>, GA101, HUMABCD20, HUMAB<CD20>, RG-7159, Ro-5072759, Gazyvaro®
Obinutuzumab, sold under the brand name Gazyva among others, is a humanized anti-CD20 monoclonal antibody used as a treatment for cancer and active lupus nephritis. It was originated by GlycArt Biotechnology AG and developed by Roche.
Research
1,389 papers- Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis.The New England journal of medicine · 2025
- Acalabrutinib-obinutuzumab improves survival vs chemoimmunotherapy in treatment-naive CLL in the 6-year follow-up of ELEVATE-TN.Blood · 2025
- Obinutuzumab as treatment for ANCA-associated vasculitis.Rheumatology (Oxford, England) · 2022
- Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.Lancet (London, England) · 2020
- A tale of two antibodies: obinutuzumab versus rituximab.British journal of haematology · 2018
via PubMed
Wikidata facts
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- chemical formula
- C₆₅₁₂H₁₀₀₆₀N₁₇₁₂O₂₀₂₀S₄₄
via Wikidata · CC0
~6 min read
Article
9 sectionsContents
- Medical uses
- Side effects
- Chemistry
- History
- Research
- Chronic lymphocytic leukemia
- Nephropathies
- References
- External links
Obinutuzumab, sold under the brand name Gazyva among others, is a humanized anti-CD20 monoclonal antibody used as a treatment for cancer and active lupus nephritis. It was originated by GlycArt Biotechnology AG and developed by Roche.
==Medical uses== As of 2015, obinutuzumab was being used in combination with chlorambucil as a first-line treatment for chronic lymphocytic leukemia. One more recent study has shown deeper and longer-lasting remissions through fixed-duration treatment regimens in combination with venetoclax.