TLR3

Name

toll like receptor 3

Type

protein-coding

Position

186,068,911–186,088,073 (+)

Aliases

CD283, IIAE2, IMD83

Ensembl

ENSG00000164342

RefSeq RNA

NM_003265.3

RefSeq protein

NP_003256.1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021].

via MyGene.info

Gene · Ensembl

toll like receptor 3

Symbol

TLR3

Biotype

Protein coding

Organism

Homo sapiens

Location

4:186,068,911-186,088,073

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

TLR3 structure.png

via Wikidata · CC0