TICAM1
Sign in to saveAlso known as IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1
TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.
Gene data
TICAM1- Name
- TIR domain containing adaptor molecule 1
- Type
- protein-coding
- Position
- 4,815,932–4,831,712 (−)
- Aliases
- IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
- Ensembl
- ENSG00000127666
- RefSeq RNA
- NM_001385678.1, NM_001385679.1, NM_001385680.1, NM_014261.1, NM_182919.4
- RefSeq protein
- NP_001372607.1, NP_001372608.1, NP_001372609.1, NP_891549.1
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TIR domain containing adaptor molecule 1
- Symbol
- TICAM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:4,815,932-4,831,749
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8605
- exact match
- identifiers.org/ncbigene/148022
- genomic end
- 4831712
- genomic start
- 4815944
- cytogenetic location
- 19p13.3
via Wikidata · CC0
~3 min read
Article
4 sectionsContents
- Structure
- Areas of research
- References
- External links
TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.
Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.