TREM1
Sign in to saveAlso known as CD354, TREM-1, triggering receptor expressed on myeloid cells 1
Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene. TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.
Gene data
TREM1- Name
- triggering receptor expressed on myeloid cells 1
- Type
- protein-coding
- Position
- 41,267,100–41,286,682 (−)
- Aliases
- CD354, TREM-1
- Ensembl
- ENSG00000124731
- RefSeq RNA
- NM_001242589.3, NM_001242590.3, NM_018643.5, NR_136332.2, XM_011514696.3
- RefSeq protein
- NP_001229518.1, NP_001229519.1, NP_061113.1, XP_011512998.1, XP_011512999.1
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
triggering receptor expressed on myeloid cells 1
- Symbol
- TREM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,267,099-41,286,703
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TREM1 PDB 1q8m.png
Show 5 more facts
- HomoloGene ID
- 10243
- exact match
- identifiers.org/ncbigene/54210
- genomic end
- 41286682
- genomic start
- 41235664
- cytogenetic location
- 6p21.1
Sources (4)
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Function
- Cancer
- Soluble TREM1
- Model organisms
- TREM1 as a Therapeutic Target
- References
- Further reading
Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene. TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.
== Function ==