TLL1

Also known as ASD6, TLL, tolloid like 1

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.

Gene data

TLL1

Name: tolloid like 1
Type: protein-coding
Aliases: ASD6, TLL

This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

via MyGene.info

Gene · Ensembl

tolloid like 1

Symbol: TLL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:165,873,058-166,105,178
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 49202
exact match: identifiers.org/ncbigene/7092
genomic start: 165873237
genomic end: 166104457
cytogenetic location: 4q32.3

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Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.