FGF4
Sign in to saveAlso known as HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF, fibroblast growth factor 4, HSTF-1
Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.
Gene data
FGF4- Name
- fibroblast growth factor 4
- Type
- protein-coding
- Position
- 69,771,022–69,775,341 (−)
- Aliases
- FGF-4, HBGF-4, HST, HST-1, HSTF-1, HSTF1, K-FGF, KFGF, SRTD22
- Ensembl
- ENSG00000075388
- RefSeq RNA
- NM_002007.4
- RefSeq protein
- NP_001998.1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
fibroblast growth factor 4
- Symbol
- FGF4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:69,771,022-69,775,344
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FGF4 PDB 1ijt.png
Show 5 more facts
- HomoloGene ID
- 1522
- exact match
- identifiers.org/ncbigene/2249
- genomic end
- 69775341
- genomic start
- 69771022
- cytogenetic location
- 11q13.3
Sources (4)
via Wikidata · CC0
~3 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.