Also known as CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
protein-coding gene in the species Homo sapiens
Gene data
KDR- Name
- kinase insert domain receptor
- Type
- protein-coding
- Position
- 55,078,476–55,125,595 (−)
- Aliases
- CD309, FLK1, VEGFR, VEGFR2
- Ensembl
- ENSG00000128052
- RefSeq RNA
- NM_002253.4
- RefSeq protein
- NP_002244.1
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
kinase insert domain receptor
- Symbol
- KDR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:55,078,144-55,125,623
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PDB 1vr2 EBI.jpg
Show 5 more facts
- HomoloGene ID
- 55639
- exact match
- identifiers.org/ncbigene/3791
- genomic end
- 55125595
- genomic start
- 55078481
- cytogenetic location
- 4q12
via Wikidata · CC0