IGF1R
Sign in to saveAlso known as CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R
protein-coding gene in the species Homo sapiens
Gene data
IGF1R- Name
- insulin like growth factor 1 receptor
- Type
- protein-coding
- Position
- 98,648,539–98,964,530 (+)
- Aliases
- CD221, IGFIR, IGFR, JTK13
- Ensembl
- ENSG00000140443
- RefSeq RNA
- NM_000875.5, NM_001291858.2, NM_152452.1, XM_011521516.3, XM_011521517.3
- RefSeq protein
- NP_000866.1, NP_001278787.1, XP_011519818.1, XP_011519819.1, XP_016877626.1
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor 1 receptor
- Symbol
- IGF1R
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:98,648,539-98,964,530
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein IGF1R PDB 1igr.png
Show 5 more facts
- HomoloGene ID
- 30997
- exact match
- identifiers.org/ncbigene/3480
- genomic end
- 99507759
- genomic start
- 98648539
- cytogenetic location
- 15q26.3
via Wikidata · CC0