IGF1R

Also known as CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R

protein-coding gene in the species Homo sapiens

Gene data

IGF1R

Name: insulin like growth factor 1 receptor
Type: protein-coding
Position: 98,648,539–98,964,530 (+)
Aliases: CD221, IGFIR, IGFR, JTK13
Ensembl: ENSG00000140443
RefSeq RNA: NM_000875.5, NM_001291858.2, NM_152452.1, XM_011521516.3, XM_011521517.3
RefSeq protein: NP_000866.1, NP_001278787.1, XP_011519818.1, XP_011519819.1, XP_016877626.1

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].