VCAM1

Also known as CD106, INCAM-100, vascular cell adhesion molecule 1

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

Gene data

VCAM1

Name: vascular cell adhesion molecule 1
Type: protein-coding
Position: 100,719,684–100,739,045 (+)
Aliases: CD106, INCAM-100
Ensembl: ENSG00000162692
RefSeq RNA: NM_001078.4, NM_001199834.2, NM_080682.3
RefSeq protein: NP_001069.1, NP_001186763.1, NP_542413.1

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

response to hypoxia chronic inflammatory response

~2 min read

Article

6 sections

Contents

Structure
Function
Pharmacology
References
Further reading
External links

==Structure== VCAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans. The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.