integrins
Sign in to saveAlso known as integrin
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (e.g. signal platelets to initiate an interaction with coagulation factors).
Key facts
- Protein family.Symbol
- Integrin_b_cyt
- Protein family.Name
- Integrin beta 7 cytoplasmic domain: complex with filamin
- Protein family.image
- PDB 2brq EBI.jpg
- Protein family.caption
- crystal structure of the filamin a repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
- Protein family.Pfam
- PF08725
- Protein family.Pfam_clan
- CL0159
- Protein family.InterPro
- IPR014836
- Protein family.SCOP
- 1m8O
- Protein family.OPM family
- 176
- Protein family.OPM protein
- 2knc
- Protein family.Membranome superfamily
- 13
- Protein family.PROSITE
- PDOC00216
- Protein family.SMART
- SM00187
- Protein family.PDB
- , , , , , , , , , , , , , ,
via Wikipedia infobox
Research
90,654 papers- Integrins in cancer: Emerging mechanisms and therapeutic opportunities.Pharmacology & therapeutics · 2023
- Integrins regulate stemness in solid tumor: an emerging therapeutic target.Journal of hematology & oncology · 2021
- Pathways of integrins in the endo-lysosomal system.Biologia futura · 2022
- Integrins in cancer treatment.Current cancer drug targets · 2006
- Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023
via PubMed
Wikidata facts
Show 1 more fact
- Commons category
- Integrins
Sources (2)
via Wikidata · CC0
~19 min read
Article
11 sectionsContents
- Structure
- Structure
- Activation
- Function
- Attachment of cell to the ECM
- Signal transduction
- Integrins and nerve repair
- Vertebrate integrins
- See also
- References
- External links
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (e.g. signal platelets to initiate an interaction with coagulation factors).
Several types of integrins exist, and one cell generally has multiple different types on its surface. Integrins are found in all animal cells while integrin-like receptors are found in plant cells.