Integrin subunit beta 3

Also known as platelet membrane glycoprotein IIIa, integrin beta-3, ITGB3, antigen CD61, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), GPIIIa, integrin beta 3, integrin beta chain, beta 3

mammalian protein found in Homo sapiens

Protein · UniProt

Integrin beta-3

Gene: ITGB3
Organism: Homo sapiens (Human)
Length: 788 aa
Molecular mass: 87,058 Da
Evidence: 1: Evidence at protein level

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation…

3D-structureAlternative splicingCalciumCell adhesionCell junctionCell membraneCell projectionDirect protein sequencing

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Swiss-Prot (reviewed) · via UniProt