PTK2
Sign in to saveAlso known as FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
Gene data
Fak- Name
- Focal adhesion kinase
- Type
- protein-coding
- Chromosome
- 2R
- Position
- 19,430,659–19,437,259 (−)
- Aliases
- CG10023, CT28129, DFAK, DFak, DFak56, Dfak, Dfak56, DmFAK, Dmel\CG10023, FAK
- Ensembl
- FBgn0020440
- RefSeq RNA
- NM_001144246.3, NM_001144247.3, NM_001169736.2, NM_079069.4, NM_166352.3
- RefSeq protein
- NP_001137718.1, NP_001137719.2, NP_001163207.1, NP_523793.2, NP_725891.1
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
- Image
- Protein PTK2 PDB 1k04.png
Show 5 more facts
- HomoloGene ID
- 7314
- exact match
- identifiers.org/ncbigene/5747
- cytogenetic location
- 56D5-56D5|2-89 cM
- genomic start
- 19430659
- genomic end
- 19437259
via Wikidata · CC0
~7 min read
Article
15 sectionsContents
- Function
- Regulation
- Role in apoptosis
- Structure
- C-terminus
- N-terminus
- Catalytic/regulatory domain
- Clinical significance
- As a drug target
- FAK inhibitors
- Interactions
- See also
- References
- Further reading
- External links
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
== Function == The PTK2 gene encodes a cytosolic protein tyrosine kinase that is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant sequence similarity to kinases from other subfamilies. It also includes a large FERM domain.