ERBB3

Name

erb-b2 receptor tyrosine kinase 3

Type

protein-coding

Position

56,076,799–56,103,505 (+)

Aliases

ErbB-3, FERLK, HER3, LCCS2, MDA-BF-1, VSCN1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3

Ensembl

ENSG00000065361

RefSeq RNA

NM_001005915.1, NM_001982.4, XM_047428500.1, XM_047428501.1, XM_054371408.1

RefSeq protein

NP_001005915.1, NP_001973.2, XP_047284456.1, XP_047284457.1, XP_054227383.1

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

erb-b2 receptor tyrosine kinase 3

Symbol

ERBB3

Biotype

Protein coding

Organism

Homo sapiens

Location

12:56,076,799-56,103,505

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein ERBB3 PDB 1m6b.png

via Wikidata · CC0