FGFR4
Sign in to saveAlso known as CD334, JTK2, TKF, fibroblast growth factor receptor 4
protein-coding gene in the species Homo sapiens
Gene data
FGFR4- Name
- fibroblast growth factor receptor 4
- Type
- protein-coding
- Position
- 177,086,456–177,098,151 (+)
- Aliases
- CD334, JTK2, TKF
- Ensembl
- ENSG00000160867
- RefSeq RNA
- NM_001291980.2, NM_001354984.2, NM_002011.5, NM_022963.3, NM_213647.3
- RefSeq protein
- NP_001278909.1, NP_001341913.1, NP_002002.3, NP_075252.2, NP_998812.1
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
fibroblast growth factor receptor 4
- Symbol
- FGFR4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:177,086,456-177,098,156
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 20461
- genomic end
- 177098144
- exact match
- identifiers.org/ncbigene/2264
- genomic start
- 177086905
- cytogenetic location
- 5q35.2
- Commons category
- Fibroblast growth factor receptor 4
via Wikidata · CC0