NTRK2
Sign in to saveAlso known as GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
protein-coding gene in the species Homo sapiens
Gene data
NTRK2- Name
- neurotrophic receptor tyrosine kinase 2
- Type
- protein-coding
- Position
- 84,668,375–85,095,751 (+)
- Aliases
- DEE58, EIEE58, GP145-TrkB, OBHD, TRKB, trk-B
- Ensembl
- ENSG00000148053
- RefSeq RNA
- NM_001007097.3, NM_001018064.3, NM_001018065.2, NM_001018066.3, NM_001291937.2
- RefSeq protein
- NP_001007098.1, NP_001018074.1, NP_001018075.1, NP_001018076.1, NP_001278866.1
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Gene Ontology
Biological process
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Alcoholism - Homo sapiens (human)PIP3 activates AKT signalingSignal TransductionSignal TransductionDisease
via MyGene.info
Gene · Ensembl
neurotrophic receptor tyrosine kinase 2
- Symbol
- NTRK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:84,668,375-85,096,069
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NTRK2 PDB 1hcf.png
Show 5 more facts
- HomoloGene ID
- 4504
- exact match
- identifiers.org/ncbigene/4915
- genomic end
- 87638505
- genomic start
- 87283466
- cytogenetic location
- 9q21.33
via Wikidata · CC0
Connections
VEGF receptors
Entity
Q180686
Entity
psychedelic drug
Entity
Brain derived neurotrophic factor
Protein
Ensembl genome database project
Entity
Erb-b2 receptor tyrosine kinase 2
Protein
KIT proto-oncogene, receptor tyrosine kinase
Protein
ERBB3
Gene
ERBB4
Gene
MET proto-oncogene, receptor tyrosine kinase
Protein
NTRK1
Gene
NTF3
Gene
tyrosine-protein kinase, neurotrophic receptor
Entity
NTRK3
Gene
TGF beta receptors
Entity
protein
Entity
International Standard Book Number
Entity
enzyme
Entity
Wikidata
Entity
epilepsy
Entity