NTRK2

Also known as GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58

protein-coding gene in the species Homo sapiens

Gene data

NTRK2

Name: neurotrophic receptor tyrosine kinase 2
Type: protein-coding
Position: 84,668,375–85,095,751 (+)
Aliases: DEE58, EIEE58, GP145-TrkB, OBHD, TRKB, trk-B
Ensembl: ENSG00000148053
RefSeq RNA: NM_001007097.3, NM_001018064.3, NM_001018065.2, NM_001018066.3, NM_001291937.2
RefSeq protein: NP_001007098.1, NP_001018074.1, NP_001018075.1, NP_001018076.1, NP_001278866.1

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].