NTF3

Also known as HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

Gene data

NTF3

Name: neurotrophin 3
Type: protein-coding
Position: 5,432,108–5,521,536 (+)
Aliases: HDNF, NGF-2, NGF2, NT-3, NT3
Ensembl: ENSG00000185652
RefSeq RNA: NM_001102654.2, NM_002527.5, XM_011520963.3, XM_047428901.1, XM_054372132.1
RefSeq protein: NP_001096124.1, NP_002518.1, XP_011519265.1, XP_047284857.1, XP_054228107.1

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

positive regulation of receptor internalization

Article

7 sections

Contents

Function
Mechanism of action
High affinity receptors
Low affinity receptors
See also
References
Further reading

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).