FGF12
Sign in to saveAlso known as FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.
Gene data
FGF12- Name
- fibroblast growth factor 12
- Type
- protein-coding
- Position
- 192,139,245–192,767,764 (−)
- Aliases
- DEE47, EIEE47, FGF12B, FHF1
- Ensembl
- ENSG00000114279
- RefSeq RNA
- NM_001377292.1, NM_001377293.1, NM_001377294.1, NM_004113.6, NM_021032.5
- RefSeq protein
- NP_001364221.1, NP_001364222.1, NP_001364223.1, NP_004104.3, NP_066360.1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
fibroblast growth factor 12
- Symbol
- FGF12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:192,139,245-192,767,764
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FGF12 PDB 1q1u.png
Show 8 more facts
- HomoloGene ID
- 10874
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2257
- genomic end
- 192485553
- genomic start
- 192139390
- chromosome
- human chromosome 3
- cytogenetic location
- 3q28-q29
- expressed in
- prefrontal cortex
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Excerpted from Wikipedia’s “FGF12” article, available under the CC BY-SA 4.0 licence.