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GeneQ14889529· pop 5· linked from 369 articles

FGF3

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Also known as HBGF-3, INT2, fibroblast growth factor 3

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

In the Vinony graph

Within Vinony's link graph, FGF3 is referenced by 369 other articles, and connects out to Q180686, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 5 Wikipedia language editions.

Gene data

FGF3

Name: fibroblast growth factor 3
Type: protein-coding
Position: 69,809,968–69,819,416 (−)
Aliases: HBGF-3, INT2
Ensembl: ENSG00000186895
RefSeq RNA: NM_005247.4
RefSeq protein: NP_005238.1

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

signal transduction cell-cell signaling positive regulation of cell population proliferation positive regulation of cell population proliferation positive regulation of cell population proliferation fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway

Molecular function

fibroblast growth factor receptor binding protein binding growth factor activity growth factor activity growth factor activity

Cellular component

extracellular region extracellular region extracellular region cytoplasm

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Melanoma - Homo sapiens (human)Breast cancer - Homo sapiens (human)Gastric cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

fibroblast growth factor 3

Symbol: FGF3
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:69,809,968-69,819,416
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3841
exact match: identifiers.org/ncbigene/2248
genomic start: 69809968
genomic end: 69819416
cytogenetic location: 11q13.3

Sources (7)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Clinical significance
Interactions
References
Further reading

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

== Function ==

Excerpted from Wikipedia’s “FGF3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 11